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Richard J Santen Selected Research

farnesylthiosalicylic acid

1/2008Adaptation to estradiol deprivation causes up-regulation of growth factor pathways and hypersensitivity to estradiol in breast cancer cells.
1/2006Farnesylthiosalicylic acid: inhibition of proliferation and enhancement of apoptosis of hormone-dependent breast cancer cells.
12/2005Farnesylthiosalicylic acid blocks mammalian target of rapamycin signaling in breast cancer cells.
1/2005Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex.

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Richard J Santen Research Topics

Disease

63Breast Neoplasms (Breast Cancer)
05/2022 - 01/2002
23Neoplasms (Cancer)
05/2022 - 02/2002
7Hypersensitivity (Allergy)
05/2022 - 09/2002
2Osteoporosis
01/2019 - 10/2017
2Atrophy
10/2017 - 05/2002
2Coronary Artery Disease (Coronary Atherosclerosis)
01/2017 - 07/2010
2Obesity
07/2015 - 06/2015
2Neoplasm Metastasis (Metastasis)
11/2010 - 05/2003
1Dysmenorrhea (Menstrual Pain)
01/2019
1Hormone-Dependent Neoplasms (Neoplasms, Hormone Dependent)
01/2019
1Hot Flashes
01/2019
1Osteosarcoma (Osteogenic Sarcoma)
10/2018
1Adrenal Insufficiency (Adrenal Gland Hypofunction)
10/2018
1Turner Syndrome (Turner's Syndrome)
01/2018
1Metabolic Bone Diseases (Osteopenia)
10/2017
1Cardiovascular Diseases (Cardiovascular Disease)
10/2017
1Sleep Wake Disorders
10/2017
1Dyspareunia
10/2017
1Rupture
01/2017
1Thrombosis (Thrombus)
01/2017
1Dementia (Dementias)
11/2015
1Coronary Disease (Coronary Heart Disease)
11/2015
1Pediatric Obesity
06/2015
1Mastodynia
06/2014
1Postmenopausal Osteoporosis
06/2014
1Noninfiltrating Intraductal Carcinoma (DCIS)
02/2014
1Hyperplasia
02/2014
1Carcinogenesis
02/2013
1Choriocarcinoma
09/2008
1Ductal Carcinoma
05/2008
1Weight Gain
06/2007
1Amenorrhea
06/2006
1Body Weight (Weight, Body)
03/2005
1Prostatic Neoplasms (Prostate Cancer)
03/2004

Drug/Important Bio-Agent (IBA)

41Estrogens (Estrogen)FDA Link
05/2022 - 05/2002
31Hormones (Hormone)IBA
05/2022 - 02/2002
20Estradiol (Delestrogen)FDA LinkGeneric
01/2018 - 02/2002
18Aromatase InhibitorsIBA
05/2022 - 09/2003
13TamoxifenFDA LinkGeneric
01/2019 - 09/2003
10Estrogen ReceptorsIBA
01/2019 - 02/2002
10Estrogen Receptor alphaIBA
07/2015 - 01/2002
7Progestins (Progestagens)IBA
01/2020 - 11/2003
7Biological ProductsIBA
09/2013 - 03/2005
6Estrogen Receptor Modulators (Antiestrogen)IBA
08/2013 - 09/2003
6Phosphotransferases (Kinase)IBA
01/2008 - 02/2002
6Proteins (Proteins, Gene)FDA Link
01/2008 - 01/2002
5mahuang-tangIBA
01/2020 - 07/2010
5Conjugated (USP) Estrogens (Premarin)FDA Link
01/2018 - 12/2012
5Aromatase (CYP19)IBA
07/2015 - 09/2003
4farnesylthiosalicylic acidIBA
01/2008 - 01/2005
4Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
12/2005 - 09/2003
3Medroxyprogesterone Acetate (Depo-Provera)FDA LinkGeneric
01/2018 - 09/2013
3EnzymesIBA
07/2015 - 05/2008
3MitogensIBA
04/2011 - 02/2002
3Pharmaceutical PreparationsIBA
01/2008 - 12/2005
3Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2008 - 01/2002
3AndrogensIBA
01/2008 - 03/2004
3Mitogen-Activated Protein KinasesIBA
08/2007 - 09/2003
2Selective Estrogen Receptor Modulators (SERM)IBA
05/2022 - 06/2014
2SteroidsIBA
01/2019 - 01/2008
2bazedoxifeneIBA
02/2013 - 12/2012
1EstetrolIBA
01/2019
1Hydrocortisone (Cortisol)FDA LinkGeneric
10/2018
1Dexamethasone (Maxidex)FDA LinkGeneric
10/2018
1Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
10/2018
1Complementary DNA (cDNA)IBA
10/2018
1GlucocorticoidsIBA
10/2018
1Dehydroepiandrosterone (DHEA)IBA
10/2017
1tiboloneIBA
10/2017
1Oral ContraceptivesIBA
12/2015
1Letrozole (Femara)FDA LinkGeneric
07/2015
1DNA AdductsIBA
07/2015
1Protein Kinases (Protein Kinase)IBA
06/2015
1Adenosine Monophosphate (AMP)IBA
06/2015
1DNA (Deoxyribonucleic Acid)IBA
03/2014
1Indicators and Reagents (Reagents)IBA
02/2014
14- (4- chloro- 2- methylphenoxy)- N- hydroxybutanamideIBA
01/2013
14-hydroxyestradiolIBA
04/2011
1Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
04/2011
1Epidermal Growth Factor (EGF)IBA
02/2010
1Guanosine Triphosphate (GTP)IBA
01/2008
1Galectin 1 (LGALS1)IBA
01/2008
1ErbB Receptors (EGF Receptor)IBA
08/2007
1IGF Type 1 Receptor (IGF 1 Receptor)IBA
08/2007
1Insulin-Like Growth Factor I (IGF-1)IBA
08/2007
1Matrix Metalloproteinases (MMPs)IBA
08/2007
1StilbenesIBA
06/2007
1Raloxifene Hydrochloride (Evista)FDA Link
06/2007
1CyclodextrinsIBA
01/2006
1TOR Serine-Threonine KinasesIBA
12/2005
1catechol (pyrocatechol)IBA
01/2005
1Phosphatidylinositols (Phosphatidylinositol)IBA
08/2004
1Estrogen Receptor betaIBA
08/2004

Therapy/Procedure

32Therapeutics
05/2022 - 09/2003
2Ovariectomy (Oophorectomy)
07/2015 - 01/2008
2Drug Therapy (Chemotherapy)
06/2006 - 03/2005
1Hormonal Contraception
01/2019
1Estrogen Replacement Therapy
01/2018
1Castration
07/2015
1Aftercare (After-Treatment)
01/2008